Anticancer Activities Of Toxic Extract Of Xestospongia testudinaria sponge From Sanur Beach, Bali, Indonesia

Xestospogiatestudinaria spongehas potentially activity as anticancer agent. According to the toxicity assay, X. testudinaria sponge methanol extract was more toxic towards Artemiasalina larvae than that of nhexane. This study aims to determine the anticancer activity of toxic extracts of X. testudinaria sponge collected from Sanur beach, Bali, Indonesia. Extraction of metabolites was conducted by room temperature using methanol. The extract was assayed its anticancer activity against HeLa cell line. The X. testudinariamethanol extract showed anticancer activity aganitsHeLa cell with IC50 value of 1.327 ppm.It was very active categories. These finding suggest that methanol extract of X. testudinariacould be used as natural anticancer towards HeLa cell, and also as a preventive therapy against diseases such as servical cancer.