EN 
IN
Journal article
Response Oxidative Stress of Ethanol Extract Abelmoschus manihot L Leaf on The Activity of Superoxide Dismutase Enzyme in Diabetic Wistar Rats
I WAYAN GEDE GUNAWAN I WAYAN PUTU SUTIRTA YASA Anak Agung Bawa Putra
Volume : 9 Nomor : 4 Published : 2018, July
Research Journal of Pharmaceutical, Biological and Chemical Sciences
Abstrak
The objective of this study was to analyze the response of oxidative stress of ethanolic extract of Abelmoschus manihot L leaves on the activity of superoxide dismutase and glutation peroxide enzyme in diabetic wistar rats. The methods of this study was laboratory experimental to analyze response of oxidative stress which was using randomized pre and post-test control group design. Data was analyzed by using One Way Anova of variance and Duncan post hoc test. The results showed that the response of ethanol extract of Abelmoschus manihot L leaves on the mean of superoxide dismutase enzyme activity in the positive control group was respectively (55,89 ± 7,38)%, treatment group each of Abelmoschus manihot L leaf extract dose of 5, 10 and 15 mg/kgbw (48,78 ± 4,19)% ; (56,31 ± 6,93)% and (76,45 ± 2,54)%. Statistically, significant with p<0.05. Ethanol extract of Abelmoschus manihot L leaf dose of 5, 10 and 15 mg/kgbw give response to the increase of superoxide dismutase enzyme activity in diabetic wistar rats. Keywords: Oxidative Stress, Abelmoschus manihot L, Superoxide dismutase, Diabetic