THE ROLE OF GLOMERULOSCLEROSIS AND TUBULAR ATROPHY AS DETERMINING FACTOR FOR REDUCED KIDNEY FUNCTION IN KIDNEY STONE DISEASE

Background : Kidney fibrosis including glomerolusclerosis (GS) and tubulointerstitial fibrosis (TIF) or tubular atrophy (TA) may be predictor of kidney dysfunction to esmate the kidney function. The aim of this research is to determine relationship between histologic features namely glomerulosclerosis (GS) and tubular atrophy (TA) and estimated glomerular filtrastion rate (eGFR) in kidney stone disease. Methods: A cross-sectional study in a total of the 63 patients with kidney stone consisted of 25 (39.7%) male and 38 960.3%) female, aged (51 = 11 years)< Blood urea nitrogen (BUN) 16 (8-62) mg/dl, serum creatinine 1.26 (0.47-6.76) mg/dl and eGFR 61.4 + 32.1 ml/min. Histologic features showed GS index 6 (0-30) and TA index 892 + 333. There was significant correlation between eGFR) and GS index and Ta index (r- 0,577; p= 0,001 and 0,514;p = 0,001, consecutively). Multivariate regresion equation were eLFG = 67,21-1.63 (GS index) and eLFG = 67,21 + 0,01 (Ta index). Estimated GFR may be used as a marker of glomerulosclerosis and tubular aatrophy in obstructive nephropathy of kidney stone patiens.