Hubungan antara TIL (Tumor Infiltrating Lymphocyte) dan MAI (Mitotic Activity Index) dengan kejadian metastase kelenjar getah bening (KGB) aksila pada operable breast cancer di RSUP Sanglah, Denpasar

Background: Evaluation of the degree of cell proliferation in tumor tissue is used to assess tumor progression. Assessment of the mitotic index has been used as a “gold standard” in assessing tumor aggressiveness. Therefore, this study aims to determine the relationship between Tumor Infiltrating Lymphocyte (TIL) and Mitotic Activity Index (MAI) with the incidence of axillary lymph node metastasis (KGB) among operable breast cancer at Sanglah Hospital Denpasar. Methods: A cross-sectional analytic studies among 53 samples of post-MRM (Modified Radical Mastectomy) breast cancer patients who were treated at Sanglah General Hospital and had medical records (clinical, histopathological data) were enrolled in this study. The eligible sampling technique was carried out on the patient’s medical record in the Department of Surgical Oncology, Faculty of Medicine, Udayana University, Sanglah General Hospital throughout 2016-2018. Data analysis of TIL and MAI with the incidence of axillary GB metastases in operable breast cancer patients was performed using SPSS version 20 software for Windows. Results: The average age of patients was 51.8 ± 10.3 years where mostly worked as housewife (50.9%) and tumor size T2 (66.0). The Chi-square test showed that patients with low TIL (P=0.627), intermediates TIL (P=0.339) and MAI ? 25/10 lp (P = 0.531), MAI 13-24 / 10 lp (P = 0.531) were not found a statistically significant association with axillary lymph node metastases. Conclusion: There was no significant association between TIL and MAI with the incidence of axillary GB metastasis in the Operable Breast Cancer at Sanglah Hospital Denpasar Keywords: TIL, MAI, metastases, axillary lymph nodes