CORDYLINE TERMINALIS KUNTH LEAVES'S SAPONIN LOWERED PLASMA CHOLESTEROL AND BILE ACIDS LEVELS BY INCREASED THE EXCRETION OF FECAL TOTAL BILE ACIDS AND CHOLESTEROL IN MALE WISTAR RATS

Saponins in the suspect can inhibit cholesterol absorption directly and indirectly in the gut so it can reduce plasma total cholesterol and bile acids, the various mechanisms that are still unclear. The purpose of this study is to prove that saponin intake of Cordyline terminalis kunth leaf, can inhibit cholesterol absorption directly and indirectly, thus lowering plasma cholesterol and total bile acids, by increasing the excretion total cholesterol and bile acids of feces. The study design was a randomized post-test only control group design, conducted in Wistar rats. Twenty-five rats were divided into four groups; Control, treatment 1, treatment 2, and treatment 3, each of 6 rats. The control group was given only the standard diet, treatment 1 was given highcholesterol foods, treatment 2 was given high-cholesterol foods and Cordyline teminalis Kunth leaf saponin 30 mg / day, and treatment 3 was given high-cholesterol foods and gemfibrozil 30 mg / day. After treatment 30 days and the rats were fasted 18 hours, blood samples were taken and plasma separated for examination of cholesterol, and bile acids. Three days last treatment the rats feces were collected for examination of total cholesterol and total bile acids. The results showed an increase in total cholesterol, LDL cholesterol, triglycerides, ratio of total cholesterol / HDL and a decrease in HDL cholesterol, and excretion fecal total cholesterol, total bile acids were significantly (p <0.05). In treatments 2 happen otherwise. Based on the results of this study concluded that the intake of saponins Cordyline terminalis Kunth leaves can inhibit the absorption of cholesterol directly and indirectly in the intestine, thus lowering plasma cholesterol and bile acids by increasing the excretion of fecal total cholesterol and total bile acids. KEYWORDS: saponins, total bile acids, total cholesterol, foods high in cholesterol.