OPTIMIZATION REGIMENT THERAPY OF PROBIOTIC AND ANTIBIOTIC COMBINATION FOR ACUTE DIARRHEA IN CHILDREN

ABSTRACT Currently a new paradigm is developed in additional therapy for acute diarrhea which can prevent pathogen bacterial colonization that causing diarrhea known as probiotic. The most common cause of acute diarrhea was bacterial infection, wherein antibiotic was used to treat the infection. Antibiotic and probiotic have contrast activities, so far there is no any standard rules regarding therapy regiment of using probiotic and antibiotic that given in one prescription. Random selection was performed to 63 pediatric patients on public hospitals, diagnosed with acute diarrhea, and getting antibiotic and pro-biotic in one prescription. Patients were divided in to three group of regiment therapy: group 1 (get probiotic 2 hours before antibiotic), group 2 (get probiotic with antibiotic at same time) and group 3 (get probiotic 2 hour after antibiotic). The effectiveness of therapy was measured from frequency and the duration diarrhea, along with volume and consistency of feces. Recurrence was observed for 3 months after the administration of probiotic and antibiotic. Data was analyzed statistically using Kruskal-Wallis test method and continued with Mann Whitney test at p < 0.05. Overall research subjects mostly boys, majority experienced by infants between 6-12 months and cephalosporin was the type of antibiotic that most often prescribe. The regiment therapy of probiotic that given 2 hours after antibiotic was proven to have significant ability (p < 0.05) in lowering frequency and duration of diarrhea, improving volume and consistency of feces compared to the administration of prebiotic 2 hours before antibiotic and in coadministration with antibiotic. There was not any different impact of regiment therapy from probiotic and antibiotic in one prescription to the recurrence of acute diarrhea on children. KEYWORDS: probiotic, antibiotic, effectiveness, recurrence. acute diarrhea, children