Pemberian rivaroxaban menurunkan kadar D-dimer pada operasi fiksasi interna tulang panjang ekstremitas bawah

Deep vein thrombosis (DVT), oftenly become post-operative complication on long bone internal fixation procedure and might leading to high morbidity to patients. D-dimer is a fibrin degradation product which may become accurate marker for DVT. This research purpose is to prove that administration of rivaroxaban in lowering D-dimer level post operatively after internal fixation of lower extremities long bone. This research is pre post experimental test with double blind sampling which consist of 40 samples, which is divided into 2 groups contains 20 samples each. First group was given 10 mg rivaroxaban per oral 6 - 10 hours post-operation, on the second group was given placebo. D-dimer level checked in 1day preoperative, 1day post-operative and 3 days post-operative. D-dimer mean measured in rivaroxabangroup, pre-operative 0.54 mg/L, 1 day post-operative 1.17 mg/L, 3 days post-operative 1.03 mg/L. D-dimer Mean result in placebo group, pre-operative 0.77 mg/L, 1 day post-operative 5.74 mg/L, 3 days post-operative 3.89 mg/L. This research using independent t-Test in pre-operative in both groups with no difference with significance of 0.07 (p > 0.05), 1 day post-operative with significance 0.002 (p < 0.05) and on 3 days post-operative with significance 0.002 (p < 0.05).This research proves that administration of rivaroxaban decreasing D-dimer level on lower extremities long bone internal fixation operation. This result support that rivaroxaban is an effective thromboprophylaxis medicamentosa to DVT.