EN 
IN
Journal article
The Differences in Level of Interleukin 6 in Lower Limb Orthopedic Surgery with General Anesthesia Technique Compared with Regional Anesthesia Combined Spinal Epidural Block Technique
Made Wiryana I Ketut Sinardja I Gede Budiarta Tjokorda Gde Agung Senapathi I Made Gede Widnyana Dennis Prakas
Volume : 5 Nomor : 12 Published : 2016, December
International Journal of Science and Research (IJSR)
Abstrak
Abstract: Background: Trauma and surgery caused tissues damage and these will trigger local and systemic inflammation as a defense mechanism and adaptation to injury. Assessment the level of interleukin 6(IL-6) as an acute phase cytokine is expected to be used as a marker of inflammation caused by the surgery.Anesthesia technique also attenuatesthe inflammatory response. Objective: to find a best anesthesia technique to minimize the inflammatory response in patient with lower limb bone’s fracture undergoing orthopedic surgery in Operating Theater of Sanglah General Hospital, Denpasar, Bali.Methods:This is anobservational study, the observation conducted from August to October 2016 in Operating Theatre of Sanglah Hospital. The study involved 28 patients who eligible with a total population sampling technique. Divided into 2 groups; 14 patients received general anesthesia (GA) and 14 patients received regional anesthesia combined spinal epidural block(RA) for the surgery. IL-6 is obtained from peripheral blood before anesthesia conducted and 24 hours after the surgery. Results:Patients received RA had a lower level of IL-6 compared to patients received GA 24 hours after surgery. Conclusion:Regional anesthesia combined spinal epidural block has a better effect of reducing inflammatory response caused by surgery compared to general anesthesia.