PERBANDINGAN DOSIS INDUKSI DAN PEMELIHARAAN PROPOFOL PADA OPERASI ONKOLOGI MAYOR YANG MENDAPATKAN

Background : General anesthesia the most technique ever done compare to other technique of anesthesia. Total Intravenous Anesthesia using propofol are developed extensively, because of less PONV incidence, cost of anesthesia, and recovery time. Technique, tools and drugs are studied to decrease needs of propofol intraoperative because of life-threatening side effect of propofol, as we know PRIS (propofol related infusion syndrome), could cause fatal morbidity and mortality. Objective : To compare induction and maintenance dose of propofol needs intraoperative between gabapentin group and control group, furthermore to generalized use of gabapentin as acutely use in perioperative management. Methods : This study is using double blind clinical trial, to controled reseacher expectation and subject manipulation to the result of study. Study divided two group, gabapentin group and control group. 32 sample each group has done their major oncology surgery using same technique total intravenous propofol with TCI. Result : Dose of induction in gabapentin group have median 1,15 mg/kgbw compare to control group have median 1,48 mg/kgbw (p < 0,001). Maintenance dose to group gabapentin have mean 93,27 mcg/kgbw/minute compare to group control have mean 123,80 mcg/kgbw/minute (p < 0,001). Conclusion : Oral premedication gabapentin 600 mg effective to decrease induction and maintenance doses of propofol use in technique total intravenous anesthesia to maintain surgery. Furthermore gabapentin premedication could generalized use as agent to decrease needs of propofol intraoperative.