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IN
Journal article
Low dose ketamin
Made Wiryana I Ketut Sinardja I Gede Budiarta Tjokorda Gde Agung Senapathi I Made Gede Widnyana I Wayan Aryabiantara I Gusti Agung Gede Utara Hartawan Pontisomaya Parami Ni Putu Novita Pradnyani Adinda Putra Pradhana
Volume : 1 Nomor : 1 Published : 2017, February
Bali Journal of Anesthesiology
Abstrak
Ketamine binds non-competitive against a phencyclidine receptors bound N-methyl-D-aspartate (NMDA), a receptor that is involved in the pathophysiology of acute pain. Ketamine has been used as an intravenous anesthesia, analgesia for acute and chronic pain at a dose of subanaesthetic. Ketamine is a dissociative anesthetic produces a state with a characteristic strong analgesia, amnesia, and catalepsy. Dissociative components resulting from the efect on the limbic system and talamoneokortikal. Low- dose ketamine as known as analgesia dose ketamine or subanestesia dose is 0.2 to 0.75 mg / kg IV. At low doses, ketamine does not increase the efect psychomimetic like dissociation or deep sedation. The combination with midazolam provides satisfactory sedation, amnesia and analgesia without signifcant cardiovascular depression.