Clinical features of transient ischemic attack or ischemic stroke patients at high recurrence risk in Indonesia

Background: In Indonesia, stroke is the leading cause of death. Identification of patients with transient ischemic attack (TIA) or ischemic stroke (IS) at high risk of recurrent stroke is important as part of the disease management. The Essen Stroke Risk Score (ESRS) is one of the predictive scores to identify patients with high or low risk of recurrence. The purpose of this disease registry is to explore clinical profiles of TIA and IS patient with high risk of stroke recurrence using ESRS in Indonesia and to understand how the patients were managed as compared to the National guideline. Methods: This is a multicenter, non-interventional, prospective disease registry. The disease registry was designed to mirror real life management of TIA and stroke patients with inclusion criteria of patients 18 years old or older with recent first time TIA or ischemic stroke and with ESRS 3 or more. The follow up period was 3 months. Results: Among 395 subjects, 357 of subjects (90.38%) completed the follow up visit. Hypertension was the most prevalent risk factor (92.2%). Majority of subjects had ESRS 3 and 4 (72.2% and 23.3%, respectively). The National guideline was followed in only 32.7% of subjects in baseline and 37.3% at follow up visit. The comparison of parameters between baseline and follow up visit for 357 subjects showed clinical improvement. Conclusion: This registry showed the clinical profiles of TIA and IS in Indonesian patients. An ESRS of 3 was recorded in majority of the subjects. Majority of subjects were not treated according to the National guideline.