UMBI UBI JALAR UNGU BALI (Ipomoea batatas) DI TRANSAMINASE SERUM, MALONDIALDEHIDE HEPAR DAN ALKOHOL KRONIS (Balinese Purple Sweet Potato (Ipomoea batatas L) on SGOT, SGPT, MDA level and Chronic Alcohol)

ABSTRACT Oxidative stress as a consequence of chronic alcoholic intake causes lesions of liver tissue. The objective of this study was to identify the antioxidant effect of ethanol extract derived from Balinese purple sweet potato on the liver tissue in mice after chronic consumption of alcohol. Subjects of this study were 32 adults male Swiss mice (12–14 weeks) divided into 4 groups with control group post-test only design. Post-treatment of blood and liver samples were collected from each group of 8 mice. The MDA liver was quantified with thiobarbituric acid reactive substances (TBARS) method. Samples were collected from control group of 8 mice without sweet potato extract and alcohol, 8 mice with 1 mg extract of Balinese purple sweet potato, 8 mice with 0.8 gram alcohol, and 8 mice with combine of alcohol and extract of Balinese purple sweet potato, each treatment was carried out every day for 4 weeks. The results showed a significant increase of serum SGOT, SGPT and liver MDA level, after chronic consumption of alcohol (p = 0.00). The decrease of serum SGOT, SGPT and liver level MDA was significant in the group with extract of Balinese purple sweet potato (p = 0.00). The researchers concluded that the extract of Balinese purple sweet potato had an antioxidant effect in mice which consumed alcohol chronically. Based on this study it is concluded that extract of Balinese purple sweet potato has a protective effect on the liver cell in mice which consumed alcohol chronically. Key words: Chronic alcohol consumption, Balinese purple sweet potato, SGOT, SGPT, liver MDA