The Prospect of Immunoglobulin Y Utilization for Therapy Canine parvovirus Infection in Dogs
24/02/2015 Views : 230
I GUSTI AYU AGUNG SUARTINI
Canine parvovirus
(CPV) is a highly infectious virus. The virus contributes to death in dogs
worldwide. The death rate due to infection of CPV in dog reaches 91%.
Prevention of CPV infection in puppies have been done by vaccination which is
proven effective, but infection still occurs mainly in unvaccinated puppies.
Protective mechanisms of maternal antibodies contribute to the failure of
vaccination. Highly stable characteristics of parvo virus enables the virus
still exist in the environment. Until now, there has not been any effective
therapeutic agent to prevent death due to CPV infection. Various therapies are
performed only suppressed the clinical symptoms but can not prevent the death
of a dog, especially in puppies. Intravenous immunoglobulin Y (IgY) therapy has
shown to suppress the spread of the CPV infection and prevent the death of the
dog. Immunoglobulin Y will neutralize the virus, so it can not infect host cells. This review will discuss CPV
alternative therapy and the
advatages using of IgY
specific antibodies isolated from chicken egg yolk.
Key words: Parvovirus, canine, immunotherapy, immunoglobulin Y