The effects of inflammatory factors on the formation of retinopathy of prematurity

Background: Retinopathy of prematurity (ROP) is the major cause of blindness in neonates worldwide. The incidence of preterm birth in live-born infants in Cipto Mangunkusumo Hospital in 2007 was 20.22%, and 71% of preterm babies have repaired retinopathy of prematurity.

Aim: This literature review aims to determine the effects of inflammatory factors on the formation of retinopathy of prematurity, such as interleukin-6, interleukin-1, COX-2 and Tumor Necrosis Factor-Alpha (TNF-α).

Conclusion: Hopefully, the information would help construct a more comprehensive approach toward patients with ROP.