Behavior Physiology Knowledge for Better Understanding of Human Inflammatory Response Status

Behavior Physiology Knowledge for Better Understanding of Human

Inflammatory Response Status

Corresponding author: Susy Purnawati

email: susy_purnawati@unud.ac.id

        The human inflammatory response is a physiological response to prevent further damage and restore the body's condition to a physiological state, or in other words to recover from an illness. This human capability is known as the mechanism of self-defense. The mechanism is also related to human behavior.

        Human behavior likely reflexes individual differences in neural physiologic brain structures or functions, or both. There are highly interconnected brain structures modulated by neurotransmitters, neuropeptides, and hormones in correlation with human behavior (Takahashi, 2014). This interconnection would be likely more complicated due to its role to drive the hypothalamic-pituitary-adrenal axis that has the interconnection to inflammation response.

        Patients with any serious illness, especially malignancy, or any disease that is felt scary or causes worry will have an impact on their behavior, and stimulate an inflammatory response that can even be exaggerated which can worsen the patient's condition. Understanding behavioral physiology as the basis for giving treatment or carrying out the management of patients provides a better chance of improving the patient's condition. When a patient is diagnosed with malignancy or another stigmatic diagnosis, they generally experience psychological distress, and anxiety, the hypothalamic-pituitary-adrenal (HPA) axis is stimulated, and the hormone cortisol is overproduced with all its effects, which if not anticipated can result in high production of free radicals which stimulate inflammatory reactions. Likewise, patients who experience complaints of pain for various reasons, refuse the illness they are experiencing, or worry about death, can give a similar response.

    Several recent scientific articles consistently report of changes in the immune status of patients with serious illnesses who experience anxiety/depression. Whatever the form of the patient's behavior by itself describes a certain biological mechanism that occurs in his body. It is very unwise when we judge the patient has made up certain complaints. Just needed to observe and analyze their behavior. Because even if a malingering reaction appears in a patient, it also requires the attention of a therapist. Because, it is still illustrating that biologically there is a mechanism underlies the malingering behavior among them. High levels of dopamine (a kind of neurotransmitter) in patients/individuals for various reasons, the chronic use of testosterone also has an impact on the patient's behavior which often looks aggressive and also requires the attention of the therapist to prevent the appearance an emergency of self-aggressive behavior. Conversely, very low dopamine levels can suppress the supply of the body's energy system mechanism which also affects the body's immune system and the patient's inflammatory status. Ignoring patient complaints and their behavior will result in us losing some data as a basis for carrying out adequate treatment to restore the patient's in physiological condition.

        It could be a conclusion that clinically-based patient management, the pathophysiology and understanding of behavioral physiology information are very useful in helping to improve the patient's inflammatory status, providing opportunities for healing and a sense of a safe feeling that gives peace to the patient.

                                                                                                                                                                                                                                                                                          Susy Purnawati, MD.

                                                                                                                                                                                                                                                                    Lecturer Staff at Physiology Department,      

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