Variable Number Tandem Repeats (VNTR) MAOA Gene Promoter Polymorphism Association with Adolescent Delinquency in Bali A Preliminary Study

One of the genes that concernbehavioral problems is the MAOA. Animal studies have shown that increased dopaminergic and noradrenergic function is associatedwith aggressive behavior.It is therefore obviousthat any change in the catabolism function possessed by MAOAcan lead to aggressive behavior. Individuals with decreased or increased MAOA function in most cases had a 30 bpsof VNTR (Variable Number Tandem Repeat) polymorphism on the MAOA gene promoter.Children with 3R or5R alleles are more likely to develop into violent behavior than thosewith alleles of 3.5R or 4R. Aim: The study aims to determine the proportion of VNTR polymorphism of MAOA gene promoter with juvenile delinquency in Bali and the relationship between VNTR polymorphism of MAOA gene promoter with juvenile delinquency in Bali. Method: The populations in this study wereadolescents (12-18 years old) divided into case and control group matched by age and sex. Participants were asked to provide a blood sample for DNA extraction. The analysis on MAOA data cannotbe conducted because the outgoing data is a constant.Result:All samples in the grouphad a high activity (100%) and only twosamples (4.6%) had heterozygous genotyping, as well as the statistical analysis,could not be performed.Conclusion: This study has not been able to answer the hypothesis, because it was unableto be analyzed. The analysis cannotbe fixed because all the measurements obtained arehomogeneous