Relationship of Hair Zinc Levels in Children With Drug Resistant Epilepsy in Sanglah Hospital

        Treatment of symptoms such as epilepsy with OAE is symptomatic, which can only suppress seizure activity, but does not cure the disease. Remission (cure) with OAE treatment only reaches 60-70%, while around 30-40% of cases experience drug resistant epilepsy (ERO) or does not work with drugs. Zinc is an important substance in the human body that has an important role in the nervous system. The lack of zinc levels in the body affects the occurrence of neurological disorders, including epilepsy, and low levels of zinc can increase the incidence of seizures in epilepsy sufferers. Research on the relationship of zinc levels with epilepsy has not been done much in Indonesia, especially in Bali. The zinc status assessment carried out in previous studies uses serum / blood to assess zinc levels. The level of zinc in serum / blood tends to vary according to daily intake. The use of tissue such as hair is better to be used as a sample for examination of zinc levels in the body because hair can store zinc more stable and longer. Based on this, this study aims to analyze the relationship of hair zinc levels with the incidence of drug resistant epilepsy (ERO) in children with epilepsy at Sanglah Hospital Denpasar.