The Leaf Extract of Datura matel L as a Potential Anaesthetic in Dogs

This study aim to evaluate the  extract of Datura matel, L as a potential anaesthetic in dogs. The quality of anaesthesia and duration of actions of anaesthesia were evaluated on twenty-five dogs. The observed pharmacological effect of the extract administered injection to twenty-five dogs that were randomly divided into five groups. Group P1 and P2 was induced intramuscular by extract of Datura matel, L at dose 20 and 40 mg/kg respectively. Group P3 and P4 was induced intramuscular by combination anaesthesia with xylazine (2 mg/kg), 15 minute later was induced  with extract of Datura matel, L at dose 20 and 40 mg/kg respectively. Goup P5 was induced intramuscular by combination anaesthesia with atropine (0.03 mg/kg)-xylazine (2 mg/kg) in one syringe, 15 minute later was induced  with ketamine 15 mg/kg.  Anaesthesia with extract of Datura matel, L at dose 20 and 40 mg/kg showed analgesia and minimal sedation, but not showed relaxation in dogs. Combination anaesthesia with xylazine (2 mg/kg), 15 minute later was induced  with extract of Datura matel, L at dose 20 and 40 mg/kg showed rapid and smooth inductions (5 minute), prolonged duration of surgical stage (52,32 and 60,83 minute ), and rapid recovery (40,30 and 48,81 minute), and causes non significant different for heart rate, respiratory rate, rectal temperature, blood oxygen saturation (SpO2 ), capillary refill time (CRT). Combination intramuscular anaesthesia by xylazine (2 mg/kg), 15 minute later was induced  with extract of Datura matel, L at dose 20 and 40 mg/kg showed minimal  anaesthesia effect. The combination of xylazine and extract of Datura matel, L were found to be suitable as an application for anaesthesia in dogs.