Mechanism of salicylic acid release, antibacterial activities and toxicities of Salicylic Acid-Bentonite Clay Nanocomposite

In an effort to develop research in the field of health and medicine, the use of natural materials both organic and inorganic as a drug delivery system receives serious attention because it can reduce systemic toxicity caused by the use of conventional medicines. Previous research has synthesized salicylic acid bentonite nanocomposite material which has a supportive character as a drug delivery system. Furthermore, this research will study how the mechanism of salicylic acid release in vitro from the bentonite clay framework (drug release system) in intestinal and gastrointestinal fluid conditions. The mechanism of the release system was studied using bag dialysis, and analysis with UV. It was also observed how the antibacterial activity of the Salicylic Acid- Bentonite Clay  nanocomposite bacteria against staphylococcus aureus bacteria and the cytotoxic activity of SABC nanocomposites by the Brain Shrimp Lethal Toxicity (BSLT) method, using shrimp larvae of artemia salina leach. Characteristics of the physical chemical properties of SABC nanocomposites were also observed to see the extent of changes that occur due to the release of salicylic acid from the tetrahedral bentonite framework.

This study aims to determine the overall characteristics of SABC nanocomposites, namely the release mechanism (drug release system), antibacterial activity and cytotoxic properties so that the ability of SABC nanocomposites as a substitute for conventional salicylic acid is more competent and promising. The results of the study are expected to be able to overcome the problem of systemic toxicity caused by salicylic acid.