White Blood Cell Survival of mice (Mus musculus L) To Adaptation Doses Gamma Co-60

Several studies of the effects of low-dose radiation have shown a shift in the three main paradigms in radiation biology. One of them is a phenomenon known as adaptation response. The phenomenon of adaptation response is a response that occurs when changes in gene expression can be induced by exposure to low doses of radiation around <0.5Gy. Changes in the expression of this gene in certain circumstances serve to protect cells against the effects caused by subsequent radiation exposure with higher doses (dose challenges). The purpose of this study is to obtain a radiotherapy method that can show a decrease in patient dosage. In this study, samples of mice (mus muscullus l) were divided into 6 groups: 1 control group and 3 treatment groups. Three treatment groups were given an adaptation dose of 0.05Gy for treatment I; 0,10Gy treatment II and treatment III; 0.15Gy. Furthermore, all direct treatments were given a 3Gy challenge dose. After the radiation is carried out, a laboratory test is performed on the blood samples of mice for white blood cells (leukocytes). Data analysis was performed to determine the amount of cell survival against the challenge dose given, as a basis for determining the radiotherapy method.