EFFECTIVENESS OF YOGA IN INCREASING ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR (EDHF) LEVELS IN DIABETES MELLITUS TYPE 2 POPULATIONS IN DENPASAR

The incidence of type 2 diabetes mellitus continues to
increase. Diabetes mellitus cause macrovascular and microvascular
complications. Long-term complications in diabetes can lead to increased
morbidity, mortality and the influence of the country's economy globally.
Complications that occur in type 2 diabetes are caused by the imbalance in the
factors that play a role in maintaining normal homeostasis of blood vessel
walls. Researches shows that exercise can improve endothelial function by
improving the balance of vasodilator and vasoconstrictor factors. One of the
factors that play a role in blood vessel function is Endothelium-Derived
Hyperpolarizing Factor (EDHF). One type of physical training that is modified
and is believed to have a positive impact on health is yoga. The long-term goal
of this study is to reduce the complications that occur in populations with
type 2 diabetes mellitus by taking precautions to do physical training namely
yoga by proving the effectiveness of a current type of physical training by
measuring markers at the biomolecular level. The specific purpose of this study
is to determine the effectiveness of yoga in increasing levels of
Endothelium-Derived Hyperpolarizing Factor (EDHF). Research method used to
achieve these objectives is to carry out research and publish the results
obtained. The targeted output is the research results and publication so that
they can be applied in a real way to the community. Description of the proposed
activity plan that is conducting research with an experimental research design
with a total sample of 30 people. The study was conducted for 12 weeks, where
EDHF measurements were taken before and after treatment. EDHF examination is
carried out by ELISA technique which will be conducted in the biomolecular
laboratory of Medical Faculty of Udayana University. The data will be analyzed
in order to obtain research results which will be published later.

 

Keywords: Yoga, EDHF, Endothelial dysfunction.