The Association between CD10 Expression and Histological Grade in Invasive Breast Carcinoma of No Special Type

Breast carcinoma is the commonest malignancy in women. Histological grade is one of independent prognostic factor of its. Breast carcinoma is an epithelial malignancy, however stromal plays an important role in breast carcinoma progression. Stromal marker is now emerging as a new marker in assessing the prognosis of breast carcinoma. Stromal CD10 expression associated with more aggressive tumor behavior. Some studies linking CD10 expression with histological grade still show conflicting result. The aim of this study was to prove the association between CD10 expression and histological grade in invasive breast carcinoma of no special type. This study was performed using a cross sectional observational analytical method. Immunohistochemical staining of CD10 was performed in 50 samples invasive breast carcinoma of no special type that met inclusion and exclusion criteria. The study results were analyzed with Chi-Square test with significancy level at p < 0.05. The highest number of cases were in the 40-50 years (44%) age group. There was an association between the CD10 expression and histological grade (p=0.001; p<0.05). Assessment of CD10 expression can be used as a marker of tumor aggression levels based on histological grade, so it could determine prognosis and for more effective therapies.