An Expression of Protein 53 (P53) did not Correlate with Staging of Ovarian Cancer

Abstract Obstetrics and Gynecology Department, Faculty of Medicine Udayana University, RSUP Sanglah Bali *Corresponding Author’s E-mail: dr.igsw@yahoo.com It analyzes the correlation protein 53 (p53) expressions and staging of ovarian cancer. A cross-sectional study of Obstetrics and Gynecologic, Pathology Anatomy and Medical Record in Sanglah General Hospital, Denpasar, conducted from July 2011 to December 2013 with a total of 44 paraffin blocks sample. Paraffin block samples are grouped based on the stage of ovarian cancer: ovarian cancer stage I, II, III, and IV. Then each group did p53 expression examination by immunohistochemical techniques. Then we do further assessment of the correlation between p53 and stage of ovarian cancer by using Spearman Test. Average age, body mass Index (IMT), parity, history of hormonal contraceptives in four group stage of ovarian cancer is homogeneous. Based on the test of correlation obtained a value of r =- 0,099 (p = 0,522) indicated that there was no relationship between the ovarian cancer stages with p53 expression. P53 Expression is not associated with the staging of ovarian cancer. Keywords: p53 expression, stages of ovarian cancer