Validity of brain Magnetic Resonance Imaging (MRI) scoring system in differentiating glioblastoma from brain metastasis in adult patients

Glioblastoma (GBM) and brain metastases are common primary and secondary brain tumors, respectively, often exhibiting overlapping radiological features. Histopathology remains the gold standard for diagnosis, but limitations arise in inoperable cases, necessitating alternative diagnostic methods. While advanced MRI sequences can aid in differentiation, their availability may be limited. This study aims to develop and validate a brain MRI scoring system utilizing readily available sequences to differentiate GBM from brain metastases based on histopathological confirmation accurately.