Metabolomic profiling as a predictor of oocyte quality in assisted reproductive technology

Human follicular fluid provides a key environment for follicular development and oocyte maturation and contributes to oocyte quality and in vitro fertilization (IVF) outcome. This study aims to understand better the role of metabolomic profiling in assessing oocyte quality in IVF program. Many biochemical materials can be isolated from follicular fluid. The concentration of each material varies. The concentration of intra-follicular material has a positive or negative effect on the oocytes quality. Many study reported that biochemical materials in follicular fluid were correlated with oocyte quality. Measurement of intrafollicular biomarker levels is more accurate and better for assessing oocyte quality. Compared with the morphological parameters, the cellular and molecular predictors of oocyte quality have been proven to be more precise and objective, further studies and refinement of techniques are still needed. Keywords: metabolomic, follicular fluid, oocyte quality, in vitro fertilization