COMPARISON OF CERUMEN AND OFLOXACIN EARDROPS BACTERICIDAL TESTS AGAINSTSTAPHYLOCCOCUS AUREUSANDPSEUDOMONASAERUGINOSABACTERIA

BSTRACT Background:Cerumen or earwax is a mixture of sebaceous gland secretions (fat) and apocrine (ceruminous)glands with epithelial debris. This combination of compositions forms an acidic layer (normal pH of 6.8), which helpsprevent infection of the ear canal. Cerumen contains various antimicrobial factors, which also prevent infection. Thisstudy aims to compare bactericidal activity on cerumen and ofloxacin in vitro inStaphylococcus aureusandPseudomonasaeruginosa.Method:The study used a type of in vitro laboratory experimental research to compare bactericidal activityin cerumen and ofloxacin drops againstStaphylococcus aureusandPseudomonas aeruginosa.Result:Based on the researchresults forStaphylococcus aureusbacteria, the average inhibition capability of cerumen was 0.7±2.1 mm. At the same time,the average inhibition capability of ofloxacin was 32.9±0.9 mm. For the bacteriumPseudomonas aeruginosa, the averageinhibition capability of cerumen is 0±0 mm. At the same time, the average inhibition capability of ofloxacin was 31.3±0.5 mm. Both variables show significant differences because both have a p-value lower than p <0.05.Conclusion:Thereare differences in inhibition capability of cerumen and ofloxacin eardrops againstStaphylococcus aureusandPseudomonasaeruginosabacteria.