The Decrease of Amyloid-Beta Deposit, Increase of Brain-Derived Neurotrophic Factor and Decrease of C-Reactive Protein Levels in the Rat Model of Dementia, Related to the Physical Exercises

Abstract Brain plasticity, also known as neuroplasticity, is a term that encompasses both synaptic plasticity and non-synaptic plasticity it refers to changes in neural pathways and synapses due to changes in behavior, environment, neural processes, thinking, emotions, as well as changes resulted from bodily injury. Dementia is a set of symptoms, which affect the way people think and interact with each other. It can often be linked to a disease of the brain. Very often, short-time memory, mind, personality change, speech and motor skills are affected. Amyloid-beta (A?) is a peptide of 36–43 amino acids, that is crucially involved in Alzheimer’s disease (AD). A? is the main component of the amyloid plaques found in the brains of AD. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin, that supports the survival and and function of cells compromised in AD. Decreased BDNF causes defects in long-term potentiation and memory and correlates with cognitive decline. In addition to predict the event, C-Reactive Protein (CRP) can also protect dementia. The increase in the volume of cerebral blood flow in physical exercise can improve brain function and retaining plasticity. Physical exercise can reduce the risk and slow the decline in cognitive function of AD patients. The purpose of this study was to prove the improvement of brain plasticity in the dementia rat model related to the physical exercises. Comparison of A? deposit, serum BDNF, cerebrospinal fluid (CSF) BDNF, serum CRP levels, astrocytes BDNF and microglia BDNF expressions between the physical exercise and control groups were performed in a number of 33 male Wistar rats. The results of this study indicated that the physical exercises can improve brain plasticity. It was found a significant difference (p <0.001) of A?, deposition depletion in the 2 series of physical exercise compared with 1 time physical exercise groups and the group without physical exercise. The serum of BDNF, CSF BDNF, serum CRP levels, astrocytes BDNF expression in the 2 series physical exercise group were significantly different compared with 1 time physical exercise groups and the group without physical exercise, with p values equal to 0.022, 0.002, 0.720, and <0.001 respectively. No significant difference (p = 0.605) of the microglia BDNF expression in the 3 study groups.