The correlation between glucose serum level and citokine level il-6 in patient with long bone fracture and politrauma at first, third and fifth day

Politrauma is not only damage the affected organ but also has systemic effect to the distance organ because of the inflammatory process. Pain and stress due to polytrauma result in neuroendocrine, neuroimmunology and metabolic change. Neuroendocrine change marked by release of countraregulatory hormones which increase glucose serum level. While neuroimmunology marked by released of proinflammatory cytokines, one of the most reliable and spesific cytokine is IL-6. Several study of glucose and Il-6 have been performed on polytrauma but research to find the correlation between both of them never done. This is a longitudinal cross sectional study to find the correlation between glucose level and IL-6 at the first, third, and fifth day in patients with long bone fracture and polytrauma. Glucose level is measured by spectrophotometry and IL-6 level is measured by ELISA. Twenty two patients with long bone fracture and politrauma, age range 14-55(mean 34 year), no history of diabetes mellitus with normal HbA1C level (mean 5.08 %) which admitted to emergency room RSUP Sanglah. Both glucose level and IL-6 is measured at first, third, and fifth day. There was strong and significant correlation between glucose and IL-6 at first and fifth day (5.07 dan 5.20, p:0.016, p:0.013; p: 0.05). There is no significant correlation at third day although the highest mean were found at third day. From the results of the statistic analysis it can be concluded that blood glucose level can be a surrogate marker of the Il-6 at the first and fifth day in patient polytrauma with long bone fracture.