Risk Factors of Patent Ductus Arteriosus in Preterm

Abstract: Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P<0.05) as risk factors for PDA including premature rupture of membranes >12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.