Difference Expression of Galectin-3 in Various Depth of Invasion on Colorectal Adenocarcinoma in RSUP Sanglah Denpasar

Abstract: Colorectal carcinoma is the fourth leading dead of malignancy in the world, including Indonesia. The depth of invasion is one of the major prognostic factors. Galectin-3 is one of the markers that are involved in anti-apoptosis, cell adhesion,and various mechanism, such as survival, angiogenesis, proliferation, transformation, and cell migration. The purpose of this study was to determine the role of galectin-3 in depth of invasion of colorectal carcinoma. This study used analytic cross-sectional method. Forty-five samples were selected from adenocarcinoma NOS by proportional stratified random sampling. Re-diagnosis was carried out to determine depth of invasion, followed by immunohistochemical staining of galectin-3 that performed at Sentra Diagnostik Patologi Bali Laboratory. Data were analyzed by One Way Anova and Chi-square test with a value of p<0.05. One WayAnova analysis showed significantly mean difference expression of galectin-3 in various depth of invasion (p=0.006) and the highest mean difference was found in pT4. Chisquare analysis showed significantly difference expression of galectin-3 with depth of invasion (p=0.039).This study proved that galectin-3 plays a role in the depth of invasion of colorectal adenocarcinoma not otherwise specified and can be considered as an adjuvant marker to predict prognosis.