EN 
IN
Journal article
Kemampuan Ekstrak Jamur Lingzhi (Ganoderma lucidum) dalam Menghambat alpha-Glucosidase dan Pengaruhnya pada Tikus Hiperglikemia
Ratih Dwi Indriani I Nyoman Suarsana I WAYAN SUDIRA
Volume : 1 Nomor : 2 Published : 2015, June
Jurnal Veteriner
Abstrak
Lingzhi mushrooms has been widely used by community empirically for the traditional medicine for lowering blood glucose levels. The purpose of this study was to determine the ability of the lingzhi mushroom (Ganoderma lucidum) extract to inhibit ?-glukosidase hyperglycemia in rat. Lingzhi mushroom ethanol-extract were tested inhibition against ?-glucosidase using spectrophotometry method. Rats used a number of 25 were divided into five groups. Four groups of rats (P1-P4) were given 2 ml of sucrose 80% orally, and one group of rats (P0) as a negative control. Ten minutes before giving sucrose, three groups (P2-P4) of rats given the lingzhi mushroom extract of 1 ml orally at a dose of 10%, 20%, and 30% respectively, while the second groups (P1) as a positive control of hyperglycemia. After that in all groups examined blood glucose levels at 0, 10, 30, 60, 90, and 120 minute after sucrose administration. The results showed, lingzhi mushroom extract has the ability to inhibit ?-glucosidase with IC50 value of 162,01?gmL-1. Blood glucose test results showed that administration of lingzhi mushroom extract at a dose of 30% faster lowering blood glucose levels compared with a dose of 10% and 20%. Key words : Lingzhi mushroom, sucrose solution, hyperglycemia, IC50