Potential of turmeric - tamarind beverage (Curcuma domestica Val. - Tamarindus indica L.) to decrease blood glucose in hyperglycemic mice

The objectives of this study were to measure the inhibition of turmeric-tamarind beverage on the activity of ?-glucosidase enzyme, to determine the quantity of intake capable of decreasing blood glucose level and to know the effect of turmeric-tamarind beverage on blood glucose level and superoxide dismutase (SOD) in diabetic mice. The study was conducted in 3 stages with using a complete randomized design (CRD). The first stage with five treatment of concentrations turmeric-tamarind as follows: control, (10, 20, 30, 40.50) mg/kg. The second stage with 7 treatments, namely: negative control (not given turmeric-tamarind beverage and not hyperglycemic), positive control (not given turmeric-tamarind beverage and hyperglycemic), to be given turmeric-tamarind beverage of 50, 100, 150, 200 mg/kg bw on hyperglycemic condition, and positive control of hyperglycemic with using acarbose 4.5 mg/kg bw. The third stage with 4 treatments i.e. groups of mice that are not given turmeric-tamarind beverage and not diabetes, the group of mice were given turmeric-tamarind beverage and not diabetes, group of diabetic mice not given turmeric-tamarind beverage, group of diabetic mice to be given turmeric-tamarind beverage of 100 mg/kg. The results showed that turmeric-tamarind beverages have the ability to inhibit the activity of the ?-glucosidase enzyme. At a concentration of 20 ppm has the highest percentage of inhibition of the enzyme activity. Provision of turmeric-tamarind beverage of 100 mg/kg bw of mice produced the lowest decrease in blood glucose levels in hyperglycemic mice. Turmeric- tamarind beverage can reduce blood glucose levels of diabetic mice. Turmeric-tamarind beverage intake of 100 mg/kg bw mice, will cause a decrease in blood glucose level of 55.83 mg/dL, whereas in mice that is not given intake, decreased blood glucose only 22.71mg/dL. Turmeric-tamarind beverage is also able to maintain the activity of SOD enzymes and the provision of this beverage can overcome the decrease of SOD in mice liver. Keywords: turmeric and tamarind, ? - glucosidase, blood glucose, hyperglycemic, SOD enzyme