Evaluating the Antifertility Potential of Andrographolide Compounds on Male Rats Wistar

We report here that andrographolide (AND), a natural compound which is mayor containt in Andrographis paniculata (A. paniculata). AND is responsible to the pharmacology activities such us antidiabetic, antidyslipidemic, antioxidant, antiinflammatory and anticancer. This study would to know the safety effect of AND on testicular organs that will affect sperm formation in male wistar rats. It began with separation of AND in A. paniculata herb by using recrystallization method. Test rats were then grouped into normal group, AND dose 2, 6 and 18 mg / kg BW. Administration of AND compound was given for 5 weeks, and its sperm morphology, testicular weight and seminiferous tubules histopathology were observed. Based on observations, administration of AND 2, 6, and 18 mg/kg BW for 5 weeks did not affect the testicular weight and the number of spermatozoa of male Wistar rats where there was no significant difference between each group. The histopathologic results also showed that AND compound did not cause destruction of the seminiferous tubular tissue in the testicular organ. So, AND is safely administered to male wistar rats. AND did not affect the testicular weight, number of spermatozoa and semimeniferus tubular tissue morphology.