Anti-Dyslipidemia Activity of Tomato Extract in Wistar Male Albino Rats Induced Fat-Rich-Diet and Dexamethasone

Lycopene is a compound that contained in tomatoes which has pharmacological activities such as antioxidants, antiinflammatory, anticancer and anti-hyperlipidemia. Lycopene belongs to a terpenoid compound that has a long carbon chain. Lycopene is more easily attracted to non-polar solvents. The aim of this study was investigating anti-dyslipidemia activity of tomatoes extract (TE) in Wistar male rats. The parameters measured were total cholesterol (TC), triglyceride (TG), lowdensity lipoprotein (LDL), and high-density lipoprotein (HDL) levels on the 7th and 14th days of TE administration. Result: TE was made using a combination of ethanol: n-hexane: acetone resulted in only lycopene compounds was attracted. Wistar male rats were fed rich-fat-diet (RFD) for 30 days and dexamethasone 1 mg/kg BW for five days (i.p), could cause an increase in blood lipid levels. TE 15 and 50 mg/kg BB after giving 14 days can reduce levels of TC, TG, LDL, and increase HDL in the blood.