Estrous Cycle of Mice (Mus Musculus L.) Exposed by Repeated Gamma Rays Radiation

This study aims to determine the effect of a repeated gamma radiation on the estrous cycle in mice (Mus musculus L.). This research used a completely randomized design (CRD) of gamma ray treatments with a dose of 2 gray (2 gy) i.e. P0 (control), P1 (dose of 1 x 2 gray), P2 (dose of 2 x 2 gray), and P3 (dose of 3 x 2 gray). Estrous cycle was observed on the vaginal swabs with topical method. Parameter measured was estrous cycle length (days). The ANOVA test results of female mice (Mus musculus L.) estrous cycle exposed to repeated gamma radiation showed a significant difference (P = 0.002). After followed by Duncans test, there were no significant differences between control and treated mice P1 and P2, however, there was significant difference of the P3 treatment (treatment with a dose of gamma radiation 3x 2 gy). Estrous cycle becomes longer in mice (Mus musculus L.) treated with repeated gamma radiation. Keywords: estrous cycle, radiation, gamma, Mus musculus L.