The Activity of Cordyline terminalis's Leaf Extract as Antidiabetic in Obese Wistar Rats

A high-fat diet can cause obesity and type 2 diabetes mellitus. This study aimed to observe the antioxidant compounds of Cordyline terminalis’s leaf extract which have the ability to be in vitro antioxidant and antidiabetic. Phytochemical tests and IC 50 to dpph were carried out in vitro. The study was conducted in vivo using 24 female wistar rats, which were divided into 4 groups: control of normal rats, high fat diet in obese rats, extract 100 mg / kg bw and extract 200 mg / kg bw. After 30 days of research, blood samples were taken for examination of triglycerides, glucose, and free fatty acids. The results showed that methanol extract contained saponins, steroids, flavonoids, alkaloids and polyphenols. The methanol extract can reduce free radicals with IC 50 88.25 ppm. In vivo test results showed that there was a significant differences (p <0.05) in the levels of TG, glucose and free fatty acids with the treatment of methanol extract (100 mg / kg bw and 200 mg / kg bw) compared to the high fat group. Based on the results of the study, it can be concluded that the methanol extract of andong leaves contained antioxidant compounds that act as antidiabetic in obese wistar rats.