IN VITRO INHIBITORY ACTIVITY OF CINNAMON LEAF EXTRACT (CINNAMOMUM BURMANNII B.) AGAINST CANDIDA ALBICANS ATCC 10231 CAUSES CANDIDIASIS

Candidiasis is a disease created by C. albicans. This fungus has been claimed as a primary agent of oral candidiasis. Therapies on this infection have depended on the use of antifungal agents, such as fluconazole and nystatin. Application of these agents has been reported to trigger fungal resistance. Therefore alternative methods to control this fungal pathogen are urgently required. Cinnamomum burmanii has been found to contain toxic compounds, such as flavonoids, inhibitory against C. albicans. Examining the ability of C. burmanii extract to prevent C. albicans from growing in vitro was the primary goal of this study. In this experiment, there was total randomization in the design. Concentrations of C. burmanii of 10% (v/v), 20% (v/v), 30% (v/v), 40% (v/v), and 50% (w/v) were used in the experiment. Fluconazole was used as the positive control and 96% ethanol as the negative control. For each treatment, three copies were carried out. Furthermore, phytochemical screening and LC50 calculations for this plant extract were carried out. It was discovered that the best extract concentration to regulate the in vitro growth of Candida albicans was 50%..The MIC and LC50 of this plant extract were 0.4% (v/v) and 1.6%, respectively. Phytochemical compounds detected in the extract include flavonoids, polyphenols, saponins, alkaloids, terpenoids, steroids and tannins.