DIFFERENCE OF TUMOR MASS IN STADIUM IIB-IIIB SQUAMOUS CELL CERVICAL CANCER PATIENTS WHO UNDERWENT PACLITAXEL CISPLATIN AND PACLITAXEL CARBOPLATIN CHEMOTHERAPY AT SANGLAH HOSPITAL DENPASAR

Objective: One of the parameters to measure the efficacy ofthe use of platinum-based chemotherapy was the difference of tumor mass. Unfortunately, there was insufficient data about the use of rational chemotherapy medicine for cervical cancer patients at Sanglah Hospital. Therefore, research to seek more data about the difference of tumor mass was necessary. Methods: A prospective observational research was conducted at Sanglah Hospital from January until August 2016 by using consecutive sampling method. Patients qualified for the inclusive criteria were separated into two groups. They were paclitaxel cisplatin group and paclitaxel carboplatingroup. Tumor mass data was obtained from before chemotherapy I and after chemotherapy VI by using USG 2D LOGIQ V5. Data analysed was performed with SPSS 20.0 for windowswith a 95% confidence level usingWilcoxon test and Mann Whitney test. Results: The mean values of tumor mass for patients in paclitaxel cisplatin regimen group before chemotherapy I and after chemotherapy VI were 68.91+7.41 cm3and 10.62+6.82 cm3respectively(p value=0.018). The mean values of tumor mass for patients in paclitaxel carboplatin regimen group before chemotherapy I and after chemotherapy VI were 53.44+52.25 cm3and 9.18+8.23 cm3respectively(p value=0.007). Meanwhile, the mean values of the difference in tumor mass between both paclitaxel cisplatin and paclitaxel carboplatin groups were-58.29+49.93 cm3and- 44.26+51.48 cm3 Conclusion: This research showed that there was a significant difference of tumor mass before chemotherapy I and chemotherapy VI in both regimen groups. There was a bigger decrease of tumor mass in patients from paclitaxel cisplatin chemotherapy group compared to paclitaxel carboplatin group, but it was not significantly different. respectively(p value=0.242). Keywords: Tumor mass, Cervical cancer, Chemotherapy, Paclitaxel cisplatin, Paclitaxel carboplatin