The Effects of Noni (Morinda Citrifolia) Ethanol Extract Cream on Collagen Deposition in Incisional Wound Healing of Male Wistar Rats

Incisional wounds, such as post-surgery wounds are traumas that could reduce quality of life of patients and cause many complications. While often disturbed by many factors, reactive oxygen species (ROS) and unending inflammation stage is two of many contributing factors that can delay wound healing. Therefore, new natural phytochemical source is needed to accelerate the healing of wounds and minimize the risk of complications. On this experimental analytic research with control group post-test research design, twenty-four male wistar rats divided into four groups. The first group is P1 (Incisional Wound + Placebo Cream) as control, P2 (Incisional Wound + 5% Noni extract cream), P3 (Incisional Wound + 10% Noni extract cream), P4 (Incisional Wound + 20% Noni extract cream). At the end of fifteenth day of wound healing, all samples are terminated and the scar tissue is observed under the microscope with Picrosirius Red (PSR) staining. Groups that are treated with concentrations of 5%, 10%, and 20% Noni extract cream have higher mean percentage of collagen deposition compared with the placebo group. Mean percentage of group P1 is 42,49%, P2 is 54,18%, P3 is 64,89%, and P4 as high as 72,22%. Through this study, topical application of noni ethanol extract cream on incisional wounds of wistar rats gained an evidence on accelerating healing and increasing collagen deposition of the wounds compared to base cream applications only.