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IN
Journal article
Role of Caspase-3 as Risk Factors of Premature Rupture of Membranes
I Ketut Surya Negara Ketut Suwiyoga I G KAMASAN NYOMAN ARIJANA Drs. I Ketut Tunas, M.Si
Volume : 10 Nomor : 4 Published : 2017, December
Biomedical and Pharmacology Journal
Abstrak
Premature rupture of membranes (PROM) is one of the problems in the field of obstetrics, related to the prevalence, prematurity, perinatal morbidity and mortality. Causes of PROM are multifactorial and its mechanisms are not yet clear. The weakening of the membranes is suspected as a result of biochemical processes that result in remodeling and apoptosis, as well as membranes stretching. Apoptosis plays an integrated role in the occurrence of premature rupture of membranes. To investigation the role of caspase-3 in premature rupture of membranes. A case-control study with PROM as a case, and non-PROM as a control at 20-42 weeks gestation. Amniotic tissue was taken after delivery of the placenta. Immunohistochemical examination of Caspase-3 was done at Integrated Lab.Biomedic Medical Faculty of Udayana University in Bali. The study was conducted on 36 cases of PROM and 37 cases non PROM. There was no characteristic difference between the case and control groups (p>0.05). The expression of positive caspase-3 is a risk factor of PROM of 7.3 times (OR = 7.31; CI 95% = 2.64 to 20.22; p = 0.001). Caspase-3 expression is a risk factor for premature rupture of membranes.