Satu tahun kesintasan penderita limfoma non-hodgkin berdasarkan klasifikasi histopatologi working formulation

Latar belakang: Limfoma Non-Hodgkin (LNH) memiliki manifestasi dan gambaran histologi yang heterogen. Berdasarkan klasifikasi Working Formulation, LNH dibagi menjadi 3, yaitu derajat keganasan rendah, menengah, dan tinggi, yang mencerminkan derajat agresifitas LNH berdasarkan gambaran histopatologiknya. Pada beberapa studi dikatakan LNH tipe indolen cenderung tumbuh lambat dan memiliki kesintasan lebih panjang dibanding tipe yang lebih agresifTujuan: Membandingkan median kesintasan penderita LNH dari jenis sel B berdasarkan derajat keganasannya sesuai dengan klasifikasi Working FormulationMetode: Penelitian ini menggunakan desain kohort retrospektif, antara bulan Januari 2013 sampai Juli 2017 di RSUP Sanglah Denpasar. Analisis menggunakan Kaplan meier dan seluruh data dianalisis menggunakan SPSS.Hasil: Dari 88 penderita LNH, diambil 38 subyek yang eligible. Dari data didapatkan sebanyak 21 penderita (55,3%) berjenis kelamin laki-laki, dengan gambaran histopatologi terbanyak berupa Diffuse Large Cell (36,8%). Sebanyak 3 penderita (7,9%) termasuk dalam derajat keganasan rendah, 25 penderita (65,8%) termasuk dalam derajat keganasan menengah, dan 10 penderita (26,3%) dengan derajat keganasan tinggi. Median kesintasan pada LNH derajat keganasan rendah di atas 1 tahun (IK 95%), derajat keganasan menengah 271 hari (IK 95%), dan derajat keganasan tinggi 31 hari (0-72,837, IK 95%), dengan nilai p=0,133, namun kelompok dengan derajat keganasan tinggi cenderung memiliki kesintasan yang lebih rendah dibanding 2 kelompok yang lain.Simpulan: Tidak terdapat perbedaan yang signifikan kesintasan penderita LNH dengan derajat keganasan rendah, sedang, dan tinggi.Kata Kunci:Limfoma Non-Hodgkin,working formulationBackground: Non-Hodgkin’s lymphoma (NHL) often has heterogeneous histopathologic and clinical manifestations. Based on the Working Formulation classification, NHL is divided into 3 subgroup; low grade, intermediate grade, and high grade, reflecting the degree of NHL aggressiveness based on histopathologic features. In some studies said that the indolent type NHL tends to grow slowly and have longer survival than the more aggressive type.Objective: To compare the median one year survival of B-cell type NHL patients based on degree of malignancy according to the Working Formulation classificationMethods: This study used a retrospective cohort design, data was taken from the cancer registry between January 2013 and July 2017 at Sanglah Hospital Denpasar. The analysis were using Kaplan-meier and all data were analyzed using SPSS.Results: Of 88 people with LNH, 38 eligible subject were selected. From the data obtained as many as 21 patients (55.3%) were male, with the most common histopathological type were Diffuse Large Cell (36.8%). About 3 patients (7.9%) were low grade, 25 patients (65.8%) were intermediate grade, and 10 patients (26.3%) were high grade. Median survival in low-grade NHL were above 1 year, intermediate grade were 271 days (IK 95%), and high grade were 31 days (0-72.837, 95% IK), with p value = 0.133, group with high grade of malignancy tend to have lower survival than 2 other groups.Conclusions: There were no significant differences in survival of NHL patients with low, intermediate and high grade.Keywords:Non-Hodgkin’s lymphoma, working formulationJurnal Penyakit Dalam UdayanaUdayana Journal of Internal MedicineVolume 2, No 1: 2018 ; 10-14Jurnal Penyakit Dalam UdayanaUdayana Journal of Internal MedicineVolume 2, No 1: 2018 ; 28-31