The Role Of Transcription Factor in Painful Diabetic Neuropathy

Painful Diabetic Neuropathy is a condition that manifests as a painful sensation that affects most of the patient with diabetes. This condition is caused by prolonging hyperglycaemic condition, which later causing damage to nerve cell through some classical hyperglycaemic pathway. This will result in the formation of oxidative stress and AGE/ROS which is responsible for the ischaemic condition that causes the damage to nerve cells. There are transcription factors that have been studied responsible for Painful Diabetic Neuropathy, such as NF-kB, PAI-1, Nrf2, and TGF-b.