THE ROLE OF NUCLEAR FACTOR ERYTHROID 2-RELATED FACTORS (NRF2) IN DIABETIC NEUROPATHY A LITERATURE REVIEW

ABSTRACT Pain is one of the health problems common in the field of medicine. Complaints of pain themselves are subjective and can affect the quality of life of patients. Therefore, a good understanding is needed to be able to diagnose and treat pain comprehensively. Along with the changing lifestyle in the community, the prevalence of diabetes mellitus (DM) also increased. Diabetic peripheral nerve (DPN) is a complication that often occurs in people with DM. This complication is the most significant cause of morbidity and mortality in patients with DM. Several pathways are thought to have a considerable effect on the incidence of diabetic neuropathy, such as the activation of the polyol pathway from the hexosamine pathway and protein kinase C (PKC), the accumulation of advanced glycation end products (AGEs) in diabetic nerves, excessive levels of glucose and fatty acids. The last few decades of research suggest that there are transcription factors that affect the incidence of diabetic neuropathy will be discussed in this article. KEYWORDS Diabetic Peripheral Nerve, Neuropathic Pain, Diabetes Mellitus 1. Introduction Pain is one of the health problems all around the world. This is because pain is one of the reasons that cause the patent to go to the doctor. A complaint of pain itself is a subjective complaint and often influence the patient’s quality of life. Because of that, a better understanding is needed to diagnose and solve the pain comprehensively. Along with the people’s lifestyle changes, the disease-related diabetes mellitus (DM) prevalence is increasing too. This pattern changes cause the increasing of the complication risk that is caused by DM itself. The common complication is diabetic neuropathy. Diabetic neuropathy is the complication of DM, which is the most significant caused of morbidity in the diabetic patient. Diabetic neuropathy is related to severe functional impairment, Copyright ©