Cognitive Disorders with High Beta Amyloid Levels in Farmers using Organophosphate Pesticides

Abstract One of the famous tourist destinations in Bali is Jatiluwih terrace rice in Tabanan regency, with beautiful rice paddies view. Many smallholders are exposed to chronic organophosphate due to the process of mixing pesticides, spraying, and cleaning in a minimum period of 2 years. This study used a consecutive case control plan for farmers who used chronic organophosphate pesticides in the village of Penarukan Kerambitan Tabanan from January to March 2019. A total of 66 study subjects aged 40-60 years were exposed to pesticides and met the eligibility criteria. This study showed subjects with serum beta amyloid levels of more than 112.03 ng/L had a 15 times risk of experiencing neurocognitive impairment compared to subjects with serum beta amyloid levels below 112.03 ng/L and statistically significant (95% CI 3.882- 60.969; p<0,001). 29 times at risk of causing neurocognitive dysfunction after adjusting for age, education and gender. The duration of exposure ? 10 years is at risk of causing neurocognitive impairment of 2.6 times compared to the duration of exposure of less than 10 years (95% CI 0.95-7.63; p=0.005).