The Correlation between Mammaglobin a mRNA Concentration in Peripheral Blood and Clinical Stages of Breast Cancer Patients at Sanglah General Hospital

Abstract: It’s difficult to determine the state of breast cancer after complete treatment by the clinical finding alone. Mammaglobin A mRNA is one of the most simplest promising method in follow-up post-operative due to it’s specific overexpression for breast cancer. Methods: The study design was cross sectional analytic study. The samples consist of 60 breast cancer patients were analysed the peripheral blood by qRT-PCR for mRNA Mammaglobin A. Results: The average concentration of mRNA Mammaglobin A is 1902.1287 µ g/mL. The ANOVA test showed a significant differences of mean concentration of mRNA Mammaglobin A between metastatic and non-metastatic (Average difference concentration 285.71328 µ g/mL; 95% CI = 28.20960 – 543.217). Conclusion: Mammaglobin A mRNA concentration was different in metastatic and non metastastatic. Micrometastases could detect as early as possible and quantification of CTC can be done before clinically manifested. Keywords: Mammaglobin A mRNA, qRT-PCR, Clinical Stages Breast Cancer