Cancer Stem Cell-Targeted Therapy Harapan Baru Terapi Kanker

Cancer stem cell (CSC) is subpopulation of tumor cell that posses stem cell properties such as self-renewal capacity and able to produce heterogenous progeny. CSC has been said to be related to cancer development, recurrency, metastasis, and resistance to conventional therapy. Signaling pathway responsible for proliferation and differentiation of CSC are Notch, Hedgehog and Wnt pathway. CSC eradication can be achieved by administering drug or gene-specific molecule targeted to CSC-specific pathway, CSC marker, DNA repair mechanism, apoptosis inhibitor, CSC microenvironment (niche), differentiation therapy, or delivering drug as polymer conjugate (nanocarrier). Keyword: cancer stem cell, targeting, nanoparticle