Hyperglicemia IncreasedThe Expression of TLR2 mRNA and Coronin-1A Level in Lung Mice which were infected by Mycobacterium Tuberculosis

Abstract: The present study was conducted to evaluate the expression ofTLR2mRNAandCoronin-1A level in micewhich wereinfected withMycobacterium tuberculosis (M.tb) and hyperglycemia.A total of24mice weredivided into 2 groups and all were infectedwith M.tb,then control group were injectedof 5 ?l a sodium citrate buffer intraperitoneallyandtreatment groupwere injected150mg/kgbwstreptozotocin (STZ)dissolved in 5 ?lsodiumcitratebuffer intraperitoneally to make hyperglycemia.Lung tissue harvestingconductedforRT-PCR examinationfor expression of TLR2 mRNA and Coronin-1A level at 3 and 5 week. In this study found the expression of TLR2 mRNA and Coronin-1A level in mice infectedwith M.tband hyperglycemia which wereexaminedin the fifth week were signifikan higher than others. Keywords: TLR2 mRNA, Coronin-1A, Mycobacterium tuberculosis