Maternal Beta HCG Levels Day 12 After Embryo Transfer to Predict Pregnancy Outcome in In-vitro Fertilization Clinic Prima Medika, Denpasar Bali Indonesia

Many methods to predict the outcome of pregnancies achieved after assisted reproductive technology (ART) has been tested. Several serum markers have been studied in relation to pregnancy outcomes, such as ²-subunit of human chorionic gonadotropin (²-hCG), estradiol, progesterone, cancer antigen 125 (Ca-125), activins, and inhibin. Among them, ²-hCG has been proven that the most predictive factor. Prediction of pregnancy outcome is important in an assisted reproductive technology program. Pregnancy obtained through IVF with or without ICSI have a higher risk of obstetric and perinatal complications compared with spontaneous pregnancies. To determine the clinical value of maternal serum ß-hCG twelfth days after the embryo transfer and to predict pregnancy outcome. The method used was a retrospective study, in which the data was obtained from women undergoing IVF Clinic IVF Prima Medika Hospital Denpasar from January to December 2015. The non-viable pregnancy is defined as a biochemical pregnancy, ectopic pregnancy and miscarriage. Ongoing pregnancy is defined as a single pregnancy and multiple pregnancies, which reached more than a gestational age of 12 weeks. Serum ß-hCG levels measured on the twelfth day after ovum pick up (OPU) and compared between the two groups Twelve days after embryo transfer, the mean levels of ²-hCG in ongoing pregnancy group (419.7 ± 232.9 mIU/ml) was significantly higher than the group of non-viable pregnancies (44.8 ± 72.9 mIU/ml) (p < 0.005). In multiple pregnancies, the levels of ²-hCG in multiple pregnancies (683.3 ± 194.4 mIU/ml) were significantly higher than singleton pregnancies (272.7 ± 155.0 mIU/ml) (p < 0.005). Levels of maternal serum ²-hCG on the twelfth day after the embryo transfer has a good predictive value for assessing the clinical pregnancy outcomes in IVF program and helps to plan the subsequent follow-up. Keywords: levels of beta hCG day 12, embryo transfer, prediction of pregnancy outcome.