Difference in Caspase-3 Expression among Benign, Borderline and Malignant Epithelial Type of Ovarian Tumor

Abstract: Background: Ovarian tumor is a worldwideproblem and mortality due to ovaria tumor is the highest among gynaecologic malignant tumors. Epithelial type are the most common ovarian tumor. The distribution of benign ovarian epithelial tumors, borderline and malignant causes a variety of tumor characteristics that lead to difficulties in its management. One of the genes that playa role in ovarian tumors is caspase-3, which is a protease execution DNA fragmentation that malfunctioning, causing no apoptosis. The malfunction results in slowed ovarian cell death process and uncontrolled proliferation of ovarian cells that cause carcinogenesis. Research purposes: To know the differences of caspase-S expression in benign, borderline and epithelial type malignant ovarian tumor. Research methods: A cross-sectional study was conducted fr9m?to. 'fin block samples of benign, borderline and malignant type of ep~thelial.ovariantumor. Caspase-J expression.w~s!!!f~.tf!Jd!I¥i1 . ""'no~410chemiC?1staining. Sta~isticalanaLy_sis was perf?rmed using Chi-Square test Results: Wefound a sIKjffi.l;tl'fJ'ttIifferencein spase-I ~p,res"slOnamong benign, borderline and maltgnant epithelial ovarian tumor (p=O.008),a signific(liwJdif/erencebetween benign and Jali}Jilhnt epithelial ovarian tumor (p = 0,004). We did not flnd a significant differences of caspase-J Ixpression between benign and borderline (p = 0,304) as well as between malignant and borderline epithelial type ovarian tumors (p = 0,215). Conclusion: Caspase-S expression was higher in benign epithelial type ovarian tumor and lower in borderline and malignant epithelial type of ovarian tumor.