Pregnane-X-Receptor Genotype and Hepatotoxic Incidence on Tuberculosis Patients Receiving Antituberculosis in Bali

Background: Drug-induced liver injury might lead to serious illness. One of the drugs that potentially toxic to the liver is antituberculosis. Many factors could influence antituberculosis-induced liver injury, including genetic variation. One of such genetic variation is polymorphism of pregnane-x-receptor (PXR) gene. PXR plays a crucial role in the regulation of many drug metabolizing enzymes and drug transporters. The association between PXR polymorphism and hepatotoxic incidence in several studies showed the inconsistent result. Therefore, it’s very important to study the PXR genotype pattern and its relation with hepatotoxic incidence among tuberculosis patients who received antituberculosis treatment. This study aimed to investigate the incidence of hepatotoxic according to PXR genotype pattern among tuberculosis patients who received antituberculosis treatment in Bali. Methods: This study was a cross-sectional study. About 65 subjects were enrolled in this study, selected from tuberculosis patients who attended the pulmonary outpatient clinic of Sanglah Hospital, Bali Indonesia and received the antituberculosis drug. Identification of PXR genotype was performed using PCR/RFLP technique with MboI restriction enzyme. Results: The proportion of wild type and mutant genotype of PXR were 72.3% and 27.7%, respectively. There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR. Conclusion: There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR on tuberculosis patients who received antituberculosis in Bali. Keywords: Pregnane-x-receptor; Polymorphism; Hepatotoxic; Antituberculosis.